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The Orioles left the bases loaded in both the third and fourth innings, then stranded two more in the fifth.
Wieters committed a pair of throwing errors as the Orioles surrendered a pair of unearned runs.
The White Sox have split first four games at U.S. Cellular Field this season after finishing with the American League's second-worst home record last year at 36-45. Chicago has won five of their last six games.
The Orioles won their only series in Chicago last season, but wound up winning five road series overall. Baltimore won two of three at Toronto over the weekend.
NOTES: Reliever Tsuyoshi Wada will continue his rehab from a left elbow impingement with a rehab outing Thursday for Triple-A Norfolk. Baltimore manager Buck Showalter expects him to be activated later this month. . Reimold was held out of the starting lineup because leg cramps, but pinch hit for Endy Chavez in the seventh.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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