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Gay answered with 28 seconds to go with a 10-foot jumper on the right baseline over Paul, ending a drought where the Grizzlies went nearly 9 minutes without a field goal.
Tony Allen fouled Paul, sending him to the line for the clinching free throws.
Boston came back from 21 down after three quarters against New Jersey on May 25, 2002.
The Grizzlies had won six straight overall and the last 11 on their home floor to grab the No. 4 seed and start this series at home. Mayo said there would be no sleep until they fix what went wrong.
"We turned something that we worked so hard for -- home-court advantage -- to an ugly loss in Game 1," Mayo said. "We've got to come back Game 2 with the attitude we can't quit."
The Grizzlies seemed to be clicking all across the board. They even hit 11 of 16 from 3-point range after ranking 25th in the NBA this season beyond the arc at 34.5 percent. Against the Clippers, they opened by hitting their four. So did Conley, and he hit three straight, the last with 7:19 left in the third, putting the Grizzlies up 69-48.
Memphis fans couldn't have been more ready for this chance to start the postseason at home with a sellout crowd on hand. With a good luck charm in a St. Jude patient singing the national anthem, fans had their free T-shirts on and waving the free towels before tipoff.
The Grizzlies were ready too. They opened the game hitting their first five shots and seven of the first 10 in jumping out 15-6, forcing Del Negro to take a timeout. They quickly led by as much as 20 and had a 34-16 lead by the end of the first quarter, tying the most points scored this season in that period.
This is the Clippers' first trip to the postseason since 2006. Paul has plenty of playoff experience with 23 games while in New Orleans, but this was the postseason debut for three starters -- Griffin, Randy Foye and DeAndre Jordan -- along with four of their teammates.
Paul looked a little rusty in the first half with only one point and three assists, all in the first quarter. He sat out the Clippers' final game of the season with a strained groin, and Los Angeles lost that game to the Knicks along with the chance to start this series at home. Paul picked up his third foul with 6.5 seconds left in the first half.
The Clippers made a run in the second quarter and got within 50-39. But after Gay missed a pull-up jumper, the Clippers had a shot clock violation. The Grizzlies scored the final eight points, the last on a dunk by Gasol just before the buzzer for a 58-39 halftime lead.
NOTES: The Grizzlies scored 34 in a quarter three other times. ... The Grizzlies went 17-1 when leading after the first and 16-1 when leading at halftime. The lone loss came in double overtime March 13 to the Lakers. ... The Grizzlies made nine 3-pointers twice during the season, the last on April 3 against Golden State.
[Associated Press;
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