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Jose Altuve had three singles for Houston, but Marwin Gonzalez followed by hitting into a double play all three times.
The Astros, owners of the worst record in baseball, have dropped 26 of their last 29 road games and are 12-48 away from home this season.
Chicago's Brett Jackson tied the game at 1 with a two-out triple in the second inning. The low liner skipped past center fielder Brandon Barnes and Castro trotted home from third.
It was Jackson's first career RBI. He also doubled in the sixth. The 24-year-old has struggled since being called up from Triple-A Iowa on Aug. 5. He was just 4 for 28 with 16 strikeouts before the triple.
NOTES: The Cubs fired vice president of player personnel Oneri Fleita. Fleita had been with the organization since 1995. . Astros RHP Francisco Cordero flew to Miami to complete his U.S. Citizenship. Cordero has been on the 15-day disabled list since Aug. 3 with a sprained toe ligament. He was acquired from Toronto on July 20. . After an off-day Thursday, Travis Wood (4-8, 4.52 ERA) pitches the series opener for the Cubs in Cincinnati against the Reds' Bronson Arroyo (8-7, 3.95). . Dallas Keuchel (1-4, 5.29) will start for Houston at home on Friday against Arizona's Wade Miley (12-8, 3.02).
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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