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Guthrie said giving up the first hit did not deflate him.
"That's a tough ground ball there," he said. "I didn't think Esky would get to it. When he got to it, I knew we had a shot at it and it just didn't work out.
"It was a tough play. He played himself into the chance to get an error or an hit. It went the way the scorer scored it. If he scored it a hit, great. If he scored it an error, great. My goal was to finish out the game with zero runs."
The Royals regained the lead with three runs in the bottom half. Billy Butler led off with a walk and was replaced by Jarrod Dyson, who swiped second for his 23rd stolen base in 26 attempts and scored on Perez's single to center off Jesse Crain (2-2).
Mike Moustakas walked and scored on a throwing error by Pierzynski. Lorenzo Cain's two-out single scored Hosmer, who reached on a walk.
Perez's double, a high chopper down the third-base line, drove in Cain and Escobar to put the Royals in front in the sixth.
Guthrie retired the first 14 batters he faced before walking Pierzynski on a full-count offering with two outs in the fifth. Alexei Ramirez broke his bat grounding out to third baseman Moustakas to end the inning.
Greg Holland (6-3) retired the final four batters to pick up the victory.
The Royals had four hits in the second inning and failed to score. Butler led off with a single, but Perez grounded into a double play. Moustakas, Jeff Francoeur and Hosmer hit consecutive singles, but Moustakas was thrown out at the plate when he attempted to score on Hosmer's hit.
NOTES: White Sox 3B Kevin Youkilis, who is nursing a sore right knee, rested. "I'm just trying to battle through something that's been barking a bit," Youkilis said. ... Yost celebrated his 58th birthday. ... Royals rookie LHP Will Smith, who has won his past two starts, will start Monday at Tampa Bay. The Rays will counter with RHP Jeremy Hellickson. ... The White Sox will start RHP Gavin Floyd on Monday when they open a homestand against the Yankees. The White Sox have lost six straight home games to the Yankees, who will start RHP Freddy Garcia.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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