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For the Patriots (1-1), third-stringer Ryan Mallett completed 10 of 20 passes for 105 yards, including a 7-yard scoring pass to Alex Silvestro. Brian Hoyer was just 5 for 17 for 55 yards.
"Ryan's a very confident player, both him and Brian," wide receiver Deion Branch said, "but it's hard for them because they have to play behind Tom Brady."
Stephen Gostkowski kicked field goals of 51, 35 and 55 yards for the Patriots, who have scored just two preseason touchdowns.
Vick's departure didn't change much for the Patriots despite his scrambling ability, defensive end Chandler Jones said.
"It's the same offensive scheme they're running," he said.
Vick wasn't the only first-stringer knocked out of the game. Philadelphia cornerback Dominique Rodgers-Cromartie and New England safety Patrick Chung went out in the first half with shoulder injuries.
The Patriots led 11-0 after Silvestro's touchdown 1:16 into the second quarter and a two-point conversion run by Shane Vereen. Then two lost fumbles within a span of just six plays led to two Eagles touchdowns.
Rookie Brandon Bolden muffed a punt, and McCoy scored three plays later. On the Patriots' second play after that, Hoyer fumbled when he was sacked by Phillip Hunt and Darryl Tapp recovered at the New England 12. Foles hit DeSean Jackson for an 11-yard completion on the next play before connecting with Harbor.
The Eagles took the lead for good, 21-14, with 3:58 gone in the third quarter on Harbor's second touchdown.
NOTES: Reid and defensive tackle Cullen Jenkins had a brief confrontation on the sideline in the first half. "He comes at you. He wants to get the best out of you," Jenkins said. "Obviously, that's not the way I should have handled it, but you just get emotional." ... A moment of silence was held before the game for Garrett Reid. The son of Philadelphia's coach was found dead Aug. 5 in his dorm room at Lehigh University, where he was helping the team's strength and conditioning coach during training camp.
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