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Tyler Flowers led off the fourth with a single and Gordon Beckham followed with a double.
De Aza hit a sharp single to right to push Chicago ahead 5-4. The White Sox won their fourth straight over the Rangers.
The teams combined for seven runs in the first two innings.
Alex Rios, who had three RBIs, gave the White Sox a 1-0 lead with a sacrifice fly. He added an RBI grounder in the seventh and a run-scoring double in the ninth.
After Hamilton's sacrifice fly tied the game at 1, Cruz capped Texas' outburst in the first with his 14th home run.
Youkilis hit a two-run shot that traveled an estimated 425 feet to center, cutting Texas' lead to 4-3 in the second.
NOTES: Chicago C A.J. Pierzynski (strained right oblique) missed his third consecutive game. . Texas 1B Mitch Moreland (strained left hamstring) continued his rehab assignment at Double-A Frisco. He took two days off to be with his wife for the birth of their child Wednesday. ... Rangers RHP Neftali Feliz, who has missed more than two months with an inflamed right elbow, will make his fourth rehab appearance Sunday for Triple-A Round Rock. Texas manager Ron Washington said the goal is to have Feliz throw 80 pitches.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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