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Nick Swisher followed with a liner to left field and Andruw Jones hit a high-arcing drive to left for a 6-0 lead. It was the first time Santana allowed three homers in a row.
Cano had two tries for a third homer but popped out and grounded out.
There was no need to worry about a pitch count for Santana. He was lifted after five innings, having allowed six runs and seven hits. He threw 86 pitches.
The two-time Cy Young Award winner has given up 19 earned runs in 14 innings and is 0-3 in three starts at the new ballpark in the Bronx.
Kuroda had a poor history against the Mets, going 1-5 with a 5.75 ERA against them with the Los Angeles Dodgers.
This time he had the Mets flailing at a slider that fooled lefties and righties. There wasn't a hard-hit ball until Quintanilla's double. The most difficult play came after Josh Thole reached on Derek Jeter's error at shortstop. David Wright broke his bat near the handle, sending much of it spiraling toward Rodriguez, while hitting a grounder to third. A-Rod calmly fielded the ball and started a double play as the bat soared over his head.
Kuroda has made three solid starts in a row, giving up just two runs in 22 innings. This time he struck out seven and walked one.
Swisher had an RBI double and Jones a run-scoring single in a three-run seventh.
NOTES: The previous time the Yankees hit back-to-back-to-back homers was Aug. 28 at Baltimore. ... Yankees reliever Joba Chamberlain threw off a mound for the first time since hurting his ankle jumping on a trampoline in March. Chamberlain made 25 throws in a batting cage at the Yankees' minor league complex in Tampa, Fla. Chamberlain, also coming off Tommy John surgery, has no doubt he will pitch this season. "Is that even a question?" he said. ... The Mets signed first-round draft pick Gavin Cecchini, giving him a $2.3 million bonus. The 18-year-old high school shortstop from Lake Charles, La., was selected 12th overall Monday night.
[Associated Press;
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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