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Strasburg faltered a bit in the second when he walked David Ortiz to start the inning, Ryan Sweeney hit a two-out single and Mike Aviles doubled off the Green Monster to drive in both runners.
"He was throwing the heck out of the ball," Washington manager Davey Johnson said. "He got a little out of sorts I thought there early in the ballgame, but came back and started really going after them."
The early Boston lead was short-lived.
After striking out in his first at-bat, Harper showed why he's among the early leaders for rookie of the year when he hit a line drive to center in the third that he stretched into a double.
Danny Espinosa, who was aboard after a leadoff walk, moved to third on Harper's play and scored on Ryan Zimmerman's single. Ian Desmond doubled to right-center to put Washington up 3-2.
Espinosa doubled in Tyler Moore in the fourth and scored on Harper's sixth homer.
Dustin Pedroia singled with one out in the sixth for Boston's first hit since the second inning, snapping an 0-for-14 slump and getting a loud cheer from Fenway fans who had watched Strasburg strike out batter after batter.
The Red Sox then caught up to Strasburg for a stretch. Gonzalez followed Pedroia with a double off the Green Monster and Ortiz walked to load the bases with one out. But the right-hander then struck out Jarrod Saltalamacchia swinging and got Kevin Youkilis looking on a 96-mph fastball.
"That's the difference between great pitchers and ones that aren't," Saltalamacchia said. "He just did a great job of getting himself out of jams."
Youkilis thought the final pitch was low and furiously argued the call before he was ejected by umpire Doug Eddings.
NOTES: Harper is the second-youngest visiting player to homer at Fenway. Robin Yount was 32 days younger when he homered here for Milwaukee in 1975. ... Strasburg also struck out 13 in a 4-2 win over Pittsburgh on May 10. ... Friday's game was the first of 15 straight Washington will play against teams from the American League East, meeting every team three times. ... Boston pitching coach Bob McClure was attending to a family matter and not with the team.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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