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The Nationals (85-52), who have the best record in the majors, remained 7 1/2 games ahead of second-place Atlanta in the NL East.
The Cubs (51-86) have lost 17 of their last 18 road games and six in a row overall. They were outscored 31-9 in the series.
"It's probably one of the biggest butt-whippings I've ever gotten in my career, as a coach or player," Sveum said. "I don't remember getting manhandled that bad in any kind of series I've been a part of."
Kurt Suzuki hit a three-run homer to help back Jordan Zimmermann (10-8), who struck out nine in seven innings. LaRoche hit his seventh home run in his last six games.
Washington tied a franchise record in each of the previous two games with six home runs.
Harper set the tone for the Nationals in the first inning Thursday, turning an apparent double into a triple and then sliding headfirst to score from third on a groundout.
"He might be the only guy that can do that," Johnson said.
Zimmermann, who allowed two earned runs and five hits, joined Gio Gonzalez and Stephen Strasburg as Washington pitchers with double-digit wins. Edwin Jackson and Ross Detwiler each have nine.
Harper also scored in the fourth inning, when he hit an infield single and came around from second on Ryan Zimmerman's two-out single.
Justin Germano (2-6) allowed seven hits and seven runs, six earned, in four innings -- his shortest start of the season.
Anthony Rizzo homered in the first on a 3-0 pitch to give the Cubs their first lead of the series.
Chicago added another run in the second on triples by Starlin Castro and Darwin Barney.
"I respect every one of those guys in the other clubhouse. But again, I think that sometimes they need to learn how to play the game a little better," Miguel Gonzalez said. "There was nothing wrong with how we're playing ball."
NOTES: Strasburg (15-6, 2.94 ERA) is scheduled to make his final home start of the season Friday against Miami rookie Jacob Turner (0-2, 6.55). Johnson doesn't expect Strasburg will change his approach. "He's all in," Johnson said. "Every time he goes out, he's committed to being the best he can be. He probably puts that standard higher than I'd like him to." ... Johnson said LHP Sean Burnett, who has been bothered by an inflamed nerve in his elbow, will play catch Saturday. ... Zimmerman extended his hitting streak to 11 games. ... Travis Wood (4-11, 4.64) will pitch for the Cubs on Friday against Pittsburgh RHP A.J. Burnett (15-5, 3.63).
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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