The Cubs' lone hit was Ryan Theriot's RBI single with two outs in the third.
The NL West-leading Dodgers recorded consecutive victories for the first time since Aug. 10-11, when they won the first two of a three-game set at San Francisco. They won two straight at home for the first time since a five-game winning streak from July 18-22.
Wolf (8-6) allowed one run, struck out five and walked two for his third consecutive victory. He was lifted after 88 less-than-overpowering pitches, getting the Cubs to swing harmlessly at strikes in the upper 80s.
He retired the first seven batters before giving up a hit and run in the third, then retired 12 of the final 13 batters he faced.
Jonathan Broxton pitched a perfect ninth for his 27th save in 32 chances.
Wolf gave himself a 2-0 lead with an RBI double to center in the second, tying a career high with his 11th RBI of the season. The two-out hit scored Russell Martin, who reached on a fielder's choice, and Orlando Hudson, who got aboard on a throwing error by third baseman Aramis Ramirez.
Sam Fuld robbed Manny Ramirez of a leadoff home run in the eighth, leaping above the fence in right-center to snag the ball.
Rookie Randy Wells (9-6) gave up two runs and seven hits in 6 2-3 innings, struck out three and walked two.
Chicago lost for the ninth time in 12 games.
NOTES: Cubs manager Lou Piniella said RHP Carlos Zambrano will return to the rotation on Tuesday against Washington. He tossed five shutout innings and allowed four hits in a rehab assignment Thursday with Class A-Peoria. ... Wolf is the first Dodgers pitcher since Fernando Valenzuela in 1990 to have 11 RBIs in a season. The left-hander last had that many in 2003 with Philadelphia. ... The Cubs fell to 10-16 against NL West opponents after going 23-10 against the West last season.