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Houston's Jacques Reeves got a 43-yard pass interference penalty on the third play of that drive.
"You can't play a half against this football team," Houston cornerback Dunta Robinson said. "We knew coming out of halftime that this game was far from over. ... (Manning) is great. He's going to find a way to not get sacked and he's going to find a way to make plays and that's what he did."
Manning finished 27 of 35 for 244 yards. Schaub was 31 of 42 for 284 yards with two TDs and two interceptions.
The Colts' first score came when Manning found Pierre Garcon for a 9-yard touchdown about six minutes before halftime. That drive was helped by a 15-yard roughing-the-passer penalty on Antonio Smith for hitting Manning in the facemask.
Houston scored on its first possession for the first time this season when Schaub completed an 11-play, 79-yard drive with a 7-yard pass to Vonta Leach to make it 7-0. The Texans marched downfield again on the next drive and went up 14-0 on a 5-yard run by Chris Brown.
Manning was under heavy pressure when he threw an interception to Brian Cushing early in the second quarter. The Texans got to the Indianapolis 12 before Kris Brown's 35-yard field goal pushed the lead to 17-0. Brown also made a 33-yard field goal in the second quarter.
"We've been really, really good and then poor in some situations, so it's my job to find some consistency," Houston coach Gary Kubiak said.
NOTES: The Colts were without star defensive end Dwight Freeney, out with an abdomen injury. ... Chris Brown and Steve Slaton combined for 113 yards rushing for Houston.
[Associated Press;
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